Head of the research group: Lead Research Scientist AGO SAMOSON
Members: Tiina Titma, Kalju Vanatalu, Andres Oss, Meelis Rohtmäe
Doctoral students: Molaiyan Palanivel, Irshad Mohammad
Topics and Competences
Keywords: micromechanics, radioengineering, technical ceramics, CAD, Alzheimer, NMR, MAS, metabolomics
NMR is a remarkably universal analytical method since essential spin interactions can be reliably calculated. The spectra allow in principle a 3D reproduction of the entire spin system and associated atoms/molecules, even a dynamics of it, given sufficient resolution and sensitivity.
The group develops NMR sensors-probeheads, notably to use the most sensitive nuclei-hydrogens, in locally viscous and solid environment. The most critical feature is rapid sample spinning. We were the first to reach rates beyond 120 kHz, getting presently over 150 kHz, which facilitates a practical inverse detection in solid state NMR. The immediate sensitivity increase is two orders of magnitude. The technology is applied in contemporary priority areas: biomedical research and development of F-ion batteries as a safer and more potent alternative for Li-based energy storage. The related key competences comprise CAD/CAM design, RF circuit modelling, technical ceramics processing and micro-machining.
In 2019 the group worked on development of NMR technologies and inhibition of fibril formation, related to Alzheimer disease.
- Malar, AA., Smith-Penzel, S., Camenisch, GM., Wiegand, T., Samoson, A., Bockmann, A., Ernst, M., Meier, BH. (2019). Quantifying proton NMR coherent linewidth in proteins under fast MAS conditions: a second moment approach. Journal of Physical Chemistry Chemical Physics. Vol. 21, Issue: 35, 18850-18865.
- Samoson, A. (2019). H-MAS. Journal of Magnetic Resonance. Vol. 306, 167-172.
- Penzel, S., Oss, A., Org, ML., Samoson, A., Bockmann, A., Ernst, M., Meier, BH. (2019). Spinning faster: protein NMR at MAS frequencies up to 126kHz. Journal of Biomolecular NMR. Vol. 73, Issue 1-2, 19-29.
- Titma, T., Shin, MJ., Ludwig, C., Gunther, UL., Pikta, M., Zemtsovskaja, G., Viigimaa, M., Tanner, R., Samoson, A. (2019). The Metabolic Profile of Stable Ischemic Heart Disease by Serum H-1 NMR. Applied Magnetic Resonance. Vol. 50, Issue 4, 527-539.