Kristine Rosenberg, a PhD candidate at the Department of Chemistry and Biotechnology, Tallinn University of Technology, will defend her dissertation titled "Complexity of Human Ovarian Folliculogenesis: Molecular Markers of Ovarian-Based Infertility and the Impact of Endocrine-Disrupting Chemicals" on October 3, 2024, at 2:00 PM. The defense will be held in room SCI-109 of the Science Building at Tallinn University of Technology (Akadeemia tee 15).
The dissertation focuses on the molecular changes occurring in the preovulatory follicles of infertile women. The study primarily involves IVF patients, particularly those whose ovaries did not respond adequately to hormonal stimulation and those diagnosed with polycystic ovary syndrome (PCOS). Additionally, it examines the presence of endocrine-disrupting chemicals (EDCs) in FF and their impact on IVF outcomes.
This dissertation contributes valuable insights into understanding how multiple factors, including changes in preovulatory follicular cell types, molecular pathways, miRNA profiles, and exposure to environmental chemicals, significantly influence ovarian sensitivity and the microenvironment for oocyte development.
The dissertation is published in the digital collection of the University Library.
Supervisor: Associate Professor Agne Velthut-Meikas, PhD (Tallinn University of Technology)
Co-supervisors:
- Professor Andres Salumets, PhD (University of Tartu)
- Ari Pekka Kalevi Sillanaukee, PhD (Nova Vita Kliinik AS)
Opponents:
- Dr. Med. Linda Gailite (Institute of Oncology and Molecular Genetics, Riga Stradiņš University, Latvia)
- Professor Angela Ivask, PhD (University of Tartu)