Development of New Optical Methods to Estimate Vascular Calcification and Monitor Inhibitors Removal During Dialysis in Patients with End-Stage Renal Disease (VasCalDi). PSG819 (01.01.2023–31.12.2027)

Annotation:

Around 13% of the adult population suffers some form of kidney damage, and the death rate of complications related to chronic kidney disease (CKD) is very high. The primary cause of death in CKD patients is cardiovascular disease. Vascular calcification (VC), one of the cardiovascular complications, is prevailing in CKD. One of the causes of VC in CKD is the disbalance between VC inhibitors and inducers due to failed kidney function. During the dialysis therapy for end-stage renal disease (ESRD) patients, inducers and also inhibitors are removed from the patients’ blood. This project (VasCalDi) aims to develop unique optical methods to estimate VC and monitor VC inhibitors removal during dialysis in patients with ESRD. The project's goal is to make the work of hospitals and physicians more efficient and improve the life quality and survival of ESRD patients by monitoring disturbances in VC inhibitor balance and vasculature allowing timely interventions.

Team: 

Principal investigator: Assistant Professor JANA HOLMAR
Senior research staff: Kristjan Pilt, Kristina Kööts, Annika Adoberg, Liisi Leis
Other research staff: Deniss Karai

Related publications:

• Leis, Liisi; Adoberg, Annika; Paats, Joosep; Holmar, Jana; Arund, Jürgen; Karai, Deniss; Luman, Merike; Pilt, Kristjan; Taklaja, Paul; Tanner, Risto; Fridolin, Ivo (2023). Hemodialysis Optical Monitoring Toward Greener Technology: A Potential for Water Saving Dialysis Treatment. In: 19th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics. (162−171). Springer. (IFMBE Proceedings; 89). DOI: 10.1007/978-3-031-37132-5_21.
• Holmar, Jana; Arund, Jürgen; Adoberg, Annika; Leis, Liisi; Luman, Merike; Paats, Joosep; Pilt, Kristjan; Tanner, Risto; Fridolin, Ivo (2023). Optical Real-Time Cardiorenal Toxin Uric Acid Measurement During Hemodialysis Using a Miniaturized Optical Sensor. 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Sydney, Australia. IEEE Xplore, 1−4. DOI: embc40787.2023.10340379.
• Pilt, Kristjan; Karai, Deniss; Bachmann, Maie; Gavriljuk, Marietta; Fridolin, Ivo (2023). Influence of Acute Mental Stress on the Forehead Photoplethysmographic Signal Waveform. In: 19th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics. (181−188). Springer. (IFMBE Proceedings; 89). DOI: 10.1007/978-3-031-37132-5_23.

• Pilt, K.; Reiu, A. (2023). Effect of transmural pressure on the estimation of arterial stiffness index from the photoplethysmographic waveform. Medical & Biological Engineering & Computing. DOI: 10.1007/s11517-023-02992-y.

Media:

• Artikkel "Neerupuudulikkusega inimeste elu võib tänu Eesti teadlastele paraneda", 17.03.2023, Digigeenius
• Intervjuu ERR Teadussaates "Labor", 12.03.2023

Overview (ETIS)